How long should mtx take to work, especially on scleritis (eye inflamation?)How long should mtx take to work, especially on scleritis (eye inflamation?)

I'm on Enbrel, sulfasalazine, prednisone, and have recently added mtx to try to get my eye under control. It has been red and inflamed for 3 months. After 3 weeks of mtx my dose went up to 20 mg, and after 4 weeks total I have seen no improvement. I'm worried it is not going to work at all, and not sure what the next step would be.

Answers from our Doctors

Dr. Ted Mikuls says:

Unfortunately, there is very little trial data examining the use of methotrexate (or other medicines for that matter) in the treatment of scleritis complicating rheumatoid arthritis. In the treatment of rheumatoid arthritis per se, methotrexate frequently takes several weeks to months to show a significant clinical benefit. In my own clinic, I generally use optimal weekly doses of methotrexate (20 to 25 mg per week) for periods of 3-4 months before making firm decisions about effectiveness or failure. Should the addition of methotrexate eventually fail to control these symptoms or should these symptoms progress in the meantime, other immunomodulating drugs have been used with some success in certain cases and could be considered by your rheumatologist in consultation with your ophthalmologist.

Answered on: Monday, May 10, 2010 - 12:23

Comments

Commenting: Guest
07/25/2019 - 08:51

Many thanks regarding submitting this kind of fantastic write-up! I came across your internet site perfect for my own wants. It includes great and also beneficial content. Maintain the nice perform! Crawley Tax Accountants

Commenting: Guest
10/22/2019 - 12:46

If you are having problems with eyes then do proper treatment and make sure you rest more of your time. You can take a break from work. Get tips from rushmyessay.com prices about it and do rest.

Commenting: Guest
11/02/2019 - 16:06

Having read this I thought it was very enlightening. I appreciate you spending some time and energy to put this short article together. best 4k action camera

Add comment