How many alcoholic drinks per week may a person on mtx have?How many alcoholic drinks per week may a person on mtx have?

Is it relatively safe to have 1 or 2 alcoholic drinks per week if I give myself 12.5 mg of methotrexate per week?

Answers from our Doctors

mjbergman's picture
Dr. Marty Bergman says:

The official "party line" is that all alcoholic beverages are to be absolutely avoided due to the increased risk of liver toxicity. That being said, the degree of risk that 1-2 drinks per week poses has never truly been established.

Realistically, occasional, low-to-moderate alcohol intake is probably something many patients taking methotrexate are doing already. My recommendation would be to try to limit the amount of alcohol that you drink (without putting a specific number of drinks per week), recognizing that rare/occasional usage is probably of limited consequence, but with each additional drink there is an additional risk of liver damage.

Answered on: Monday, May 24, 2010 - 10:23


Commenting: Guest
08/27/2010 - 00:19

My tip is this: Do all the same habits, same beverage container, same routine, just CHANGE what's in the glass/bottle/tumbler etc. I used to love my red wine. I had 2 to 3 glasses each evening while I chatted with my husband and cooked dinner. When I started on MTX my rheumatologist said no more than 3 glasses per week. I decided that I'd be better off quitting altogether and only having a little wine on very special occasions, holidays, family get together, special celebration, that kind of thing. I used my favorite wine glass and filled it with Pelogrino. I kept the bottle of the fancy water on the counter where my wine bottle would have been. I drank the water just as if were the wine. I found that it was WAY easier to deal with the cravings when I did this. These days my cravings are long gone and my liver is happy. I have friends that this method worked for, hope it works for you. :)

Commenting: Guest
09/01/2010 - 16:34

I've been on MTX for 20+ years and have never had a rheumatologist tell me not to drink. I don't drink heavily but I do have a glass of wine or two most nights. That said, I've always had regular blood work done every 8-12 weeks to check for liver toxicity. I've always been told that that is the way around this issue.

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